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Sustained Release Agent

Name Precirol ATO 5®
Chemical Name Glyceryl Palmitostearate
Physical Appearance Atomized Powder
Melting Point 56 C
HLB 2
Regulatory Status FCC, GRAS, JSFA, EP, USP-NF, FDA IIG
Description Precirol® ATO 5 is a multifunctional excipient: a sustained release agent, lubricant and a taste masking agent for oral dosage forms.

Used at levels of 10% to 20% for the development of tablets, it forms an inert matrix which, 'in vivo', slowly releases the active through erosion/diffusion.
Used between 3% to 20% in a coating processes, such as hot melt coating (Gattecoat® process), the coated drug molecules can be formulated with other ingredients and then compressed in to tablets with sustained release properties.

 


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