Compritol® 888 Pellets: Forms a lipid matrix for sustained release formulations.
Used at levels of 10% to 20% (possibly higher), for the development of tablets, it forms an inert matrix which, 'in vivo', slowly releases the active through erosion/diffusion. Used between 2% to 20% in a coating processes, such as hot melt coating (Gattecoat® process), the coated drug molecules can be formulated with other ingredients and then compressed in to tablets with sustained release properties.
